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Aciphex



Brand vs Generic


Aciphex - antiulcer drug.
Before buy aciphex, read common information about it.
The action of the drug.
Aciphex or aciphex generic inhibits the enzyme H +-K +-ATPase, thereby blocking the final stage of the synthesis of hydrochloric acid. After oral administration of aciphex 20 mg antisecretory effect occurs within 1 h and reaches a maximum after 2-4 h. The inhibitory effect of aciphex on acid secretion slightly increased during daily administration of 1 tablet. Stable inhibition of secretion attained within 3 days after starting the drug. After stopping receiving aciphex secretory activity is restored within 2-3 days. In vitro it was found that aciphex has a bactericidal effect on H.pylori.

If you need to buy aciphex online, you must know how it works.
Pharmacokinetics.
Aciphex or aciphex generic is rapidly absorbed from the intestine. After oral doses of aciphex 20 mg Cmax in plasma is reached after about 3.5 h. The absolute bioavailability after oral administration of aciphex 20 mg is about 52% because of metabolism in the liver. In addition, bioavailability does not change with repeated admission of aciphex. Food intake and time of drug administration during the day have no effect on the absorption of aciphex.
The degree of binding to plasma proteins is approximately 97%. Half-life is approximately 1 hour. Approximately 90% of dose is excreted in the urine mainly in the form of two metabolites.

Looking for aciphex online? Read indications for use.
Indications.
- Duodenal ulcer in acute phase;
- Peptic ulcer in acute phase;
- Gastroesophageal reflux disease (GERD): erosive reflux esophagitis (healing), symptomatic treatment of GERD;
- Zollinger-Ellison syndrome or other conditions characterized by pathological hypersecretion.
In addition, aciphex in combination with antibacterial agents used:
- With Helicobacter pylori eradication in patients with gastric ulcer or chronic gastritis;
- For the treatment and prevention of recurrence of ulcers in patients with peptic ulcer associated with Helicobacter pylori.
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If you have to buy aciphex, you must know how you can use the drug.
Dosage.
If duodenal ulcer and gastric ulcer in acute phase is recommended to take 1 tab. (aciphex 20 mg), 1 time / day in the morning for 4-6 weeks.
For some patients with acute duodenal ulcer good effect gives reception 1 time / 0.5 tab.
The majority of patients with duodenal ulcer, ulcer healing occurs within 4 weeks. It should be noted, however, that some patients to ulcer healing has to take aciphex for another 4 weeks.
The majority of patients with gastric ulcer healing occurs within 6 weeks, but some patients to heal ulcers may require an additional 6-week course of treatment by aciphex generic.
For patients with GERD is recommended to take aciphex 1 tab. (20 mg) / day for 4-8 weeks. For maintenance therapy in GERD the drug is appointed in a dose of aciphex 10 mg or 20 mg 1 time / day, depending on the patient's response.
For the symptomatic treatment of GERD for patients without esophagitis aciphex is appointed in a dose of aciphex 10 mg 1 time / day for 4 weeks. If after 4 weeks of treatment, symptoms do not disappear, it is necessary to undertake further examination of the patient.
For the treatment of Zollinger-Ellison syndrome and other conditions characterized by pathological hypersecretion, the dose selected individually. The initial dose is 60 mg / day, then increase the dose and administer a dose of 100 mg / day or 60 mg 2 times / day.
For the treatment of duodenal ulcer or chronic gastritis associated with infection with Helicobacter pylori, eradication rates using multiple options, with appropriate combinations of antibiotics. We recommend a course of treatment duration of 7 days, one of the following drug combinations:
- aciphex 20 mg 2 times / day + clarithromycin 500 mg 2 times / day and amoxil 1 g 2 times / day.
- aciphex 20 mg 2 times / day + clarithromycin 500 mg 2 times / day and metronidazole 400 mg 2 times / day.
The tablets should be swallowed whole without chewing or crushing.
Patients with impaired renal or hepatic dose adjustment of aciphex generic is not required.

Side effects you must know if you buy aciphex online.
Side effects.
From the digestive system: diarrhea, abdominal pain, flatulence, dry mouth.
CNS: headache.
From hemopoiesis system: seldom - thrombocytopenia, neutropenia, leukopenia.
Dermatologic reactions: skin rash, rarely - erythema, bullous eruptions.
Based on the experience of clinical trials can be concluded that aciphex is generally well tolerated. Side effects generally mild or moderate and are transient in nature.

Aciphex online. Contraindications. - Pregnancy.
- Lactation (breastfeeding).
- Hypersensitivity to rabeprazole sodium- active ingredient of aciphex .
Aciphex is not recommended for children because there is currently no experience of its use in pediatric practice.

Overdose.
Until now, information about cases of deliberate overdose Aciphex have not been reported. Acceptance of the drug in doses of 80 mg / day had no effect on the overall condition of the patient.

Product form.
Pills.
aciphex 10 mg (Low Dosage)
aciphex 20 mg (Normal Dosage).

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